New drug reduces hot flushes in days

New drug reduces hot flushes in days

"But new analysis confirms the beneficial effect is obtained very quickly - within just three days".

A REVOLUTIONARY menopause drug cuts hot flushes by three quarters in just three days, experts have revealed.

In a clinical trial involving 37 women, the compound called MLE4901 reduced the number of hot flashes by nearly three-quarters and significantly reduced the severity.

But new analysis shows its magic works within 72 hours.

The drug blocks a chemical in the brain called neurokinin B and in the study the drug also improved sleep and concentration during the 4-week study period.

Dr Julia Prague, first author of the study, explained: "As NKB has many targets of action within the brain the potential for this drug class to really improve numerous symptoms of the menopause, such as hot flushes, difficulty sleeping, weight gain, and poor concentration, is huge".

These versions have fewer side effects than MLE4901, so the treatment Imperial has tested is not going to be taken into further trials.

New drugs could be available within years.

The menopause occurs when oestrogen levels fall, typically around 45 to 55 years of age, which leads to periods stopping, the inability to have children naturally, and a number of physical changes, including menopausal flushing and/or sweating.

Women often describe a hot flush as a creeping feeling of intense warmth that quickly spreads across the body and face "right up to your brow".

The trial was conducted on women who experienced seven or more hot flushes a day.

But for some, frequent severe episodes can leave clothes and bed sheets drenched in sweat, as well as causing sleepless nights, which has an impact on their working, social and home lives.

The new data also revealed that the drug was as effective at improving daytime flush symptoms as it was at improving night time symptoms. And findings showed that women taking the new drug had reported an 82% decrease in interrupted sleep. To see the lives of our participants change so dramatically and so quickly was so exciting, and suggests great promise for the future of this type of treatment'.

And scientists are holding out hope that the new menopause drug could be a viable alternative to hormone replacement therapy (HRT), to help ease symptoms.